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袁若 教授

发布者:西南大学 袁亚利 发布时间:2016-1-22 阅读:6755

袁若 教授 博导
E-Mail: yuanruo@swu.edu.cn
重庆市北碚区天生路2号西南大学化学化工学院
研究领域
主要从事以功能纳米材料与免疫、适体及DNA、MicroRNA及细胞结合研制电致化学发光、电化学、光致电化学生物传感器,用于疾病标志物及肿瘤细胞检测和抗肿瘤药效评价。
近年主持的科研项目
1.国家自然科学基金面上项目:自增强钌配合物电致化学发光超灵敏糖尿病肾病标志物免疫传感器研究,95.4万元,2016.1-2019.12
2.国家自然科学基金面上项目:酶催化原位生成共反应试剂增强电致化学发光的超灵敏适体传感器研究,80万元,2013.1-2016.12
5.教育部重大培育项目:超灵敏猪链球菌2型特异蛋白电化学免疫传感器关键技术研究及应用,40万元,2009.1-2010.12
6.高等学校博士学科点专项科研基金:多酶及铂纳米簇-碳纳米管复合物多重催化的超灵敏心血管疾病标志物电化学免疫传感器研究,6万元,2011.1-2013.12
7.重庆市“百名学术学科领军人才”培养计划,320万,2012.6-2016.6
近年获得的奖项
1.成果:重要肿瘤标志物蛋白电化学免疫生物传感器研究,获2012年度重庆市自然科技一等奖(排名第一)
2.成果:创伤厌氧菌感染现场快速检验关键技术及其应用,获2013年度重庆市科技进步一等奖(排名第二)
3.指导的1篇博士论文获2010年全国优秀博士论文提名论文
近年发表的代表性论文
1.Liang, W.B.; Zhuo, Y,; Xiong,C.Y.; Zheng,Y.N.; Chai, Y.Q*.; Yuan, R.*.Ultrasensitive Cytosensor Based on Self-enhanced Electrochemiluminescent Ruthenium-Silica Composite Nanoparticles for Efficient Drug Screening with Cell Apoptosis Monitoring. Anal. Chem., 2015,87,12363-12370.
2.Shen,W.J.; Zhuo, Y.* Chai, Y.Q.; Yuan, R.*.Cu-Based Metal−Organic Frameworks as a Catalyst To Construct a Ratiometric Electrochemical Aptasensor for Sensitive Lipopolysaccharide Detection. Anal. Chem., 2015, 87, 11345-11352.
3.Han, J.; Zhuo, Y*.; Chai, Y.Q.; Xiang, Y.; Yuan, R.*. New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal. Chem., 2015, 87(3), 1669-1675.
4.Chen, A.Y.; Gui, G.F.; Zhuo, Y*.; Chai, Y.Q.; Xiang, Y.; Yuan, R.*. Signal-off Electrochemiluminescence Biosensor Based on Phi29 DNA Polymerase Mediated Strand Displacement Amplification for MicroRNA Detection. Anal. Chem., 2015, 87(12), 6328-6334.
5.Zhao, M.; Liao, N.; Zhuo, Y.*; Chai, Y.Q.; Wang, J.P.; Yuan, R.*. Triple Quenching of a Novel Self-Enhanced Ru(II) Complex by Hemin/G-Quadruplex DNAzymes and Its Potential Application to Quantitative Protein Detection. Anal. Chem.. 2015, 87(15), 7602-7609
6.Xie, S.B.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*. Tracing Phosphate Ions Generated during Loop-Mediated Isothermal Amplification for Electrochemical Detection of Nosema bombycis Genomic DNA PTP1.. Anal.Chem., 2015, 87(20), 10268-10274.
7.Gui, G.F.; Zhuo, Y.*; Chai, Y.Q.; Xiang, Y.; Yuan, R.*. In situ generation of self-enhanced luminophore by β lactamase catalysis for highly sensitive electrochemiluminescent aptasensor. Anal. Chem., 2014, 86, 5873-5880.
8.Zhuo, Y.*; Liao, N.; Chai, Y.Q.;Gui, G.F.; Zhao, M.; Han, J.; Xiang, Y.; Yuan, R.*. Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal. Chem., 2014, 86, 1053-1060.
9.Chen, Y.; Xu, J.; Su, J.; Xiang, Y.*; Yuan, R.*; Chai, Y.Q.. In situ hybridization chain reaction amplification for universal and highly sensitive electrochemiluminescent detection of DNA.  Anal. Chem. 2012, 84(18), 7750−7755.
10.Xiong, C.Y.; Wang, H.J.; Liang, W.B.; Yuan, Y.L.; Yuan, R.*; Chai, Y.Q.*. Luminescence-Functionalized Metal–Organic Frameworks Based on a Ruthenium(II) Complex: A Signal Amplification Strategy for Electrogenerated Chemiluminescence Immunosensors. Chem. Eur. J. 2015, 21, 9825-9832.
11.Yuan, Y.L.; Yuan, R.*; Chai, Y.Q.; Zhuo, Y.; Gan, X.X.; Bai, L.J.. 3,4,9,10-perylenetetracarboxylic acid/hemin nanocomposites act as redox probes and electrocatalysts for constructing a pseudobienzyme-channeling amplified electrochemical aptasensor.  Chem. - Eur. J., 2012, 18(44), 14186-14191.


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